In the late 1990’s Dr. Shaheen Hamdy and his group were able to demonstrate for the first time that delivering Pharyngeal Electrical Stimulation (PES) to the nerves in the throat could result in therapeutic changes in the brain. Most importantly they showed that the positive changes they were able to cause in the brain still remained even when the stimulation was stopped. This groundbreaking research was published in one of the most prestigious scientific journals in the world read more – Nature Neuroscience 1998 May;1(1):64-8.
Clinical studies in patients soon followed and it was shown that the positive changes in the brain also led directly to improvements in swallowing function in patients with dysphagia. A very significant reduction in the amount of food or liquid accidentally entering the patients airways could be seen after treatment read more – Neuron. 2002 May 30;34(5):831-40.
The clinical trial found that after pharyngeal stimulation over 75% of patients recovered the ability to swallow safely. They showed improvements in oral nutritional intake and were able to eat more independently.
The study also found that patients who received pharyngeal stimulation left hospital an average of 5 days sooner than patients who didn’t read more.
There were no adverse events reported during any of the clinical trials. Phagenesis® is committed to ongoing research and development that will transform the lives of people with dysphagia.
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Hamdy S, Aziz Q, Rothwell JC, et al. Recovery of Swallowing after Dysphagic Stroke Relates to Functional Reorganisation in Intact Motor Cortex. Gastroenterology 1998; 115: 1104-1112 read more.
Hamdy S, Rothwell JC, Aziz Q, Sigh Kd, Thompson DG. Long-term reorganization of human motor cortex driven by short-term sensory stimulation. Nat Neurosci 1998; 1: 64-68 read more.
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Scutt P, Lee HS, Hamdy S, et al. Pharyngeal Electrical Stimulation for Treatment of Poststroke Dysphagia: Individual Patient Data Meta-analysis of Randomised Controlled Trials. Hindawi Publishing Corporation, Stroke Research and Treatment, Volume 2015, Article ID 429053, 8 pages read more.
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Vasant DH, Michou E, et al. Pharyngeal Electrical Stimulation in Dysphagia Poststroke: A Prospective, Randomized Single-Blinded Interventional Study. Neurorehabilitation and Neural Repair 1-10 2016 read more.
Michou E, Sasegbon A, et al.Direct and Indirect Therapy: Neurostimulation for the Treatment of Dysphagia After Stroke. In: . Medical Radiology. Springer, Berlin, Heidelberg 2017 read more.
Köstenberger M, Neuwersch St, et al. Dysphagia on the intensive care unit – an additional therapy option?!. ÖGARI 2017 read more.
Muhle P, Suntrup-Krueger S, et al. Increase of Substance P Concentration in Saliva after Pharyngeal Electrical Stimulation in Severely Dysphagic Stroke Patients – an Indicator of Decannulation Success?. Neurosignals 2017; 25: 74–87 read more.
Restivo DA, Hamdy S, et al. Pharyngeal electrical stimulation device for the treatment of neurogenic dysphagia: technology update. Medical Devices: Evidence and Research 2018; 11: 21-26 read more.
Dziewas R, Mistry S, et al. Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study. Int J Stroke. 2017 Jun;12(4):430-437. Epub 2016 Nov 2 read more.
Dziewas R, Stellato R, et al. Pharyngeal electrical stimulation for early decannulation in tracheotomised patients with neurogenic dysphagia after stroke (PHAST-TRAC): a prospective, single-blinded, randomised trial. Lancet Neurol.2018; Epub 2018 Aug 28 read more.