In the late 1990’s Dr. Shaheen Hamdy and his group were able to demonstrate for the first time that delivering Pharyngeal Electrical Stimulation (PES) to the nerves in the throat could result in therapeutic changes in the brain. Most importantly they showed that the positive changes they were able to cause in the brain still remained even when the stimulation was stopped. This groundbreaking research was published in one of the most prestigious scientific journals in the world read more – Nature Neuroscience 1998 May;1(1):64-8.
Clinical studies in patients soon followed and it was shown that the positive changes in the brain also led directly to improvements in swallowing function in patients with dysphagia. A very significant reduction in the amount of food or liquid accidentally entering the patients airways could be seen after treatment read more – Neuron. 2002 May 30;34(5):831-40.
The clinical trial found that after pharyngeal stimulation over 75% of patients recovered the ability to swallow safely. They showed improvements in oral nutritional intake and were able to eat more independently.
The study also found that patients who received pharyngeal stimulation left hospital an average of 5 days sooner than patients who didn’t read more.
There were no adverse events reported during any of the clinical trials. Phagenesis® is committed to ongoing research and development that will transform the lives of people with dysphagia.
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Koestenberger M, Neuwersch S, et al. A Pilot Study of Pharyngeal Electrical Stimulation for Orally Intubated ICU Patients with Dysphagia. Neurocrit Care 2019; Epub 2019 Jul 16 read more.
Zuercher P, Moret CS, et al. Dysphagia in the intensive care unit: epidemiology, mechanisms, and clinical management. Critical Care (2019) 23:103 read more.
Bath PM, Woodhouse LJ, et al. Pharyngeal Electrical Stimulation for Early Decannulation in Tracheotomised Stroke Patients With Dysphagia: A Meta-analysis of Individual Patient Data From Randomised Controlled Trials. International Stroke Conference 2020 Moderated Poster Abstracts Title: Clinical Rehabilitation and Recovery Moderated Poster Tour; 12 Feb 2020Stroke ;51:ATMP40 read more.
Everton LF, Benfield JK, Hedstrom A, et al. Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients. Sci Rep 10, 7268 (2020) read more.
Florea C, Bräumann C, et al. Therapy of Dysphagia by Prolonged Pharyngeal Electrical Stimulation (Phagenyx) in a Patient with Brainstem Infarction. Brain Sci. 2020, 10, 256 read more.
Beirer S, Grisold W, et al. Therapy-resistant dysphagia successfully treated using pharyngeal electrical stimulation in a patient with the pharyngeal-cervical-brachial variant of the Guillain-Barré syndrome. eNeurologicalSci 20 (2020) 100255 read more.